Updated 12/2025
Introduction
Trigger thumb, or stenosing tenosynovitis of the thumb, occurs when the flexor pollicis longus tendon cannot pass through the A-1 pulley smoothly.1 Whether the pulley thickens or the tenosynovium thickens and/or the tendons deform and develop a "nodule," the result is the same: loss of smooth active flexion and extension in the digit. The thumb can lock in flexion or extension or simply be difficult to move without significant pain.2,3
Thus, the trigger finger affects hand function and, in severe cases, may lead to limitations in daily routines. In patients with diabetes, the condition is more likely to affect multiple digits and both hands. Initial trigger thumb treatment can include activity modification, splinting and non-steroidal anti-inflammatory medications. Conservative treatment options may include local corticosteroids, and platelet-rich plasma injection.4 Definitive treatment frequently requires surgical release of the A-1 pulley.5
Related Anatomy
- Narrowing of flexor tendon sheath at the A-1 pulley level
- Thickening of FPL tendon at the A1 pulley level
- Histology shows non-inflammatory fibrosis; occasionally, chronic inflammatory cells are present
Relevant Basic Science
- In patients with trigger fingers the number of chondrocytes and the adjacent extracellular matrix, are notably increased, compared to non-symptomatic patients. When a tendon sheath becomes swollen, the sheath becomes fibrotic and may undergo cartilaginous metaplasia.
- The tendon becomes thinner under the area of constriction and thickens proximal to the constriction to form a “nodule.”.6,2
- While the oblique pulley is narrower by measurement, the A1 pulley is the tightest functionally because the pathological thickening occurs at this location where the tendon-pulley mismatch causes triggering.7,8
Incidence and Related Conditions
- More common in women; pregnancy is a predisposing risk factor
- Predisposing systemic conditions: rheumatoid arthritis (RA), diabetes, gout, amyloidosis, mucopolysaccharidoses and Peyronies disease.9
- Often trigger thumb is comorbid with DeQuervain’s disease and carpal tunnel syndrome.
Differential Diagnosis
- DeQuervain’s disease10
- Dupuytren’s contracture
- MP joint loose body/dislocation
- Tendon sheath tumor
- RA