Trigger finger, or stenosing tenosynovitis, occurs when the flexor tendons cannot pass smoothly through the A-1 pulley because the tendon sheath has become thickened and swollen. In the child’s thumb, this swollen portion of the tendon is referred to as a nodule or “Notta’s Node,” named after nineteenth century French physician, Alphonse Notta.1,2 This nodule is secondary to, not the cause of the primary pathology. Whether the pulley thickens or the tenosynovium thickens with fibrosis, the result is the same: loss of smooth active flexion and extension in the digit. The digit can lock, snap, click, or catch in flexion or extension or simply be difficult to move with or without significant pain.
Trigger fingers affect hand function and, in severe cases, may lead to limitations in activities of daily living. In patients with diabetes, the condition is likely to affect multiple digits and both hands. Initial treatment can include activity modification, splinting and non-steroidal anti-inflammatory medications. Nonsurgical treatment options may also include local corticosteroid injection or platelet-rich plasma injection.3 Definitive treatment most often requires surgical release of the A1 pulley through an open, endoscopic or percutaneous approach.4,5
Related Anatomy
- Histology shows non-inflammatory fibrosis; occasionally, chronic inflammatory cells are present. Pro-inflammatory cytokines like IL-β, TNF-α, and MMP’s are elevated and TGF-β is upregulated.6, 7
- Triggering is rarely caused by irregular anatomy like abnormal lumbrical insertion, a proximal decussation of flexor digitorum sublimis (FDS) tendon, or narrowing and/or thick ening of FDS tendon sheath at the A-1 pulley level.8
Current Relevant Basic Science
In patients with trigger fingers the number of chondrocytes and the adjacent extracellular matrix, especially collagen Type II and III, are notably increased compared to non-symptomatic patients.9,10 When a tendon sheath becomes swollen, the sheath becomes fibrotic and may undergo cartilaginous metaplasia. The flexor tendon becomes thinner under the area of constriction and thickens proximal to the constriction.11 These tendon changes appear to be exacerbated by repetitive microtrauma, especially with high-load activities.12,13,14,15
Incidence and Related Conditions
- The prevalence of trigger finger affects 2-3% of the population.16,17
- Triggering affects thumb and fingers, most commonly the thumb and ring finger
- Trigger fingers can occur in infants and children
- More common in women (2-6 times); pregnancy is a predisposing risk factor14
- Additional predisposing systemic conditions: rheumatoid arthritis, gout, amyloidosis, mucopolysaccharidoses
- Diabetes mellitus and hypothyroidism are also linked to trigger finger, with glycolated collagen contributing to tissue stiffness.18
- Prevalence in diabetes ranges from 5-20%.16
- Risk factors in diabetic patients include female gender, age >60, insulin use, elevated HbA1c levels, and diabetic complications like neuropathy.
- Trigger fingers are often co-morbid with DeQuervain’s disease, carpal tunnel syndrome, elbow tendinopathy, gout, and rheumatoid arthritis.19,20,21,22,23
- Repetitive trauma or work activities may play a role in the etiology of this condition; however, there is no decisive evidence to support the relationship between triggering and overuse.24
Differential Diagnosis
- DeQuervain’s disease
- Dupuytren’s contracture
- Metacarpophalangeal (MP) joint loose body/dislocation
- Proximal interphalangeal (PIP) joint dislocation
- Volar plate avulsion with entrapment
- Tendon sheath tumor
- Intrinsic tendon injury on an irregular metacarpal head
- Rheumatoid arthritis (RA)
- Ganglion cyst
- Abnormal sesamoids
- Subluxation of extensor digitorum communis
- Boxer’s knuckle
Updated - 10/2025